abstract：OBJECTIVE:To determine the effect of four monthly vitamin D supplementation on the rate of fractures in men and women aged 65 years and over living in the community. DESIGN:Randomised double blind controlled trial of 100 000 IU oral vitamin D3 (cholecalciferol) supplementation or matching placebo every four months ove...

journal_title：BMJ (Clinical research ed.)

authors： Trivedi DP,Doll R,Khaw KT

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the effectiveness of a self help approach to smoking cessation in pregnancy. DESIGN:Pragmatic cluster randomised controlled trial with community midwife as the unit of randomisation. SETTING:Three NHS hospital trusts in England. PARTICIPANTS:1527 women who smoked at the start of pregnancy. IN...

journal_title：BMJ (Clinical research ed.)

authors： Moore L,Campbell R,Whelan A,Mills N,Lupton P,Misselbrook E,Frohlich J

更新日期：2002-12-14 00:00:00

abstract：OBJECTIVES:To assess whether and how investigators of placebo controlled randomised trials inform participants of their treatment allocation at trial closure and to assess barriers to feedback. DESIGN:Postal survey with a semistructured questionnaire. PARTICIPANTS:All investigators who published a placebo controlled ...

journal_title：BMJ (Clinical research ed.)

authors： Di Blasi Z,Kaptchuk TJ,Weinman J,Kleijnen J

更新日期：2002-12-07 00:00:00

abstract：OBJECTIVE:To examine the effects of involving patients in the planning and development of health care. DATA SOURCES:Published and grey literature. STUDY SELECTION:Systematic search for worldwide reports written in English between January 1966 and October 2000. DATA EXTRACTION:Qualitative review of papers describing ...

journal_title：BMJ (Clinical research ed.)

authors： Crawford MJ,Rutter D,Manley C,Weaver T,Bhui K,Fulop N,Tyrer P

更新日期：2002-11-30 00:00:00

abstract：OBJECTIVES:To understand the approaches to learning of practising physicians in their workplace and to assess the relation of these approaches to their motivation for, preferred methods of, and perceived barriers to continuing medical education. DESIGN:Postal survey of 800 Ontario physicians. PARTICIPANTS:373 physici...

journal_title：BMJ (Clinical research ed.)

authors： Delva MD,Kirby JR,Knapper CK,Birtwhistle RV

更新日期：2002-11-23 00:00:00

abstract：OBJECTIVES:To determine the strength of evidence for the effectiveness of mental health interventions for patients with three common somatic conditions (chronic fatigue syndrome, irritable bowel syndrome, and chronic back pain). To assess whether results obtained in secondary care can be extrapolated to primary care an...

journal_title：BMJ (Clinical research ed.)

authors： Raine R,Haines A,Sensky T,Hutchings A,Larkin K,Black N

更新日期：2002-11-09 00:00:00

abstract：OBJECTIVE:To systematically evaluate the published evidence regarding the characteristics and effectiveness of disease management programmes. DESIGN:Meta-analysis. DATA SOURCES:Computerised databases for English language articles during 1987-2001. STUDY SELECTION:102 articles evaluating 118 disease management progra...

journal_title：BMJ (Clinical research ed.)

authors： Weingarten SR,Henning JM,Badamgarav E,Knight K,Hasselblad V,Gano A Jr,Ofman JJ

更新日期：2002-10-26 00:00:00

abstract：OBJECTIVE:To explore the suitability of a screening based intervention for excessive alcohol use by describing the experiences of general practitioners who tried such an intervention in their everyday practice. DESIGN:Qualitative interviews with general practitioners who had participated in a pragmatic study of a comb...

journal_title：BMJ (Clinical research ed.)

authors： Beich A,Gannik D,Malterud K

更新日期：2002-10-19 00:00:00

abstract：OBJECTIVE:To assess the associations between childhood and adulthood social class and insulin resistance. DESIGN:Cross sectional survey. SETTING:23 towns across England, Scotland, and Wales. PARTICIPANTS:4286 women aged 60-79 years. MAIN OUTCOME MEASURES:Insulin resistance and other cardiovascular disease risk fact...

journal_title：BMJ (Clinical research ed.)

authors： Lawlor DA,Ebrahim S,Davey Smith G,British women's heart and health study.

更新日期：2002-10-12 00:00:00

abstract：OBJECTIVE:To determine whether the more intensive screening and treatment for prostate cancer in the Seattle-Puget Sound area in 1987-90 led to lower mortality from prostate cancer than in Connecticut. DESIGN:Natural experiment comparing two fixed cohorts from 1987 to 1997. SETTING:Seattle-Puget Sound and Connecticut...

journal_title：BMJ (Clinical research ed.)

authors： Lu-Yao G,Albertsen PC,Stanford JL,Stukel TA,Walker-Corkery ES,Barry MJ

更新日期：2002-10-05 00:00:00

abstract：OBJECTIVE:To assess the association between genotype at the insertion or deletion polymorphism of the angiotensin converting enzyme gene and risk of coronary restenosis after percutaneous coronary intervention. DESIGN:Meta-analysis of studies before July 2001 that reported on these genotypes and risk of coronary reste...

journal_title：BMJ (Clinical research ed.)

authors： Bonnici F,Keavney B,Collins R,Danesh J

更新日期：2002-09-07 00:00:00

abstract：OBJECTIVE:To study the processes involved in and impact of mergers between NHS trusts, including the effect on management costs. DESIGN:Cross sectional study involving in depth interviews and documentary analysis; case study to compare savings in management costs between case trusts and control trusts. SETTING:Nine t...

journal_title：BMJ (Clinical research ed.)

authors： Fulop N,Protopsaltis G,Hutchings A,King A,Allen P,Normand C,Walters R

更新日期：2002-08-03 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of early treatment for amblyopia in children. DESIGN:Follow up of outcomes of treatment for amblyopia in a randomised controlled trial comparing intensive orthoptic screening at 8, 12, 18, 25, 31, and 37 months (intensive group) with orthoptic screening at 37 months only (control ...

journal_title：BMJ (Clinical research ed.)

authors： Williams C,Northstone K,Harrad RA,Sparrow JM,Harvey I,ALSPAC Study Team.

更新日期：2002-06-29 00:00:00

abstract：OBJECTIVES:To evaluate the effect of daily zinc supplementation in children on the incidence of acute lower respiratory tract infections and pneumonia. DESIGN:Double masked, randomised placebo controlled trial. SETTING:A slum community in New Delhi, India. PARTICIPANTS:2482 children aged 6 to 30 months. INTERVENTIO...

journal_title：BMJ (Clinical research ed.)

authors： Bhandari N,Bahl R,Taneja S,Strand T,Mølbak K,Ulvik RJ,Sommerfelt H,Bhan MK

更新日期：2002-06-08 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of two mechanical methods of blood conservation in reducing the need for allogeneic red blood cells or coagulation products during cardiac surgery. DESIGN:Randomised controlled trial. SETTING:Regional cardiac centre in a teaching hospital in Southampton. PARTICIPANTS:263 adults ...

journal_title：BMJ (Clinical research ed.)

authors： McGill N,O'Shaughnessy D,Pickering R,Herbertson M,Gill R

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of a teacher led intervention to improve teenagers' knowledge about emergency contraception. DESIGN:Cluster randomised controlled trial. SETTING:24 mixed sex, state secondary schools in Avon, south west England. PARTICIPANTS:1974 boys and 1820 girls in year 10 (14-15 year olds)....

journal_title：BMJ (Clinical research ed.)

authors： Graham A,Moore L,Sharp D,Diamond I

更新日期：2002-05-18 00:00:00

abstract：OBJECTIVES:To gain insight into people's thoughts on stroke and to inform the development of educational strategies in the community. DESIGN:Focus group discussions: two groups of people who had a stroke and their carers, and two groups of members of the general public. SETTING:New South Wales, Australia. PARTICIPAN...

journal_title：BMJ (Clinical research ed.)

authors： Yoon SS,Byles J

更新日期：2002-05-04 00:00:00

abstract：OBJECTIVES:To investigate the perspectives of patients with asthma on the use of an action plan and the implementation of this plan during an asthma attack that culminated in a visit to an emergency department. DESIGN:Qualitative study. SETTING:Tertiary teaching hospital, suburban hospital, and rural hospital. PARTI...

journal_title：BMJ (Clinical research ed.)

authors： Douglass J,Aroni R,Goeman D,Stewart K,Sawyer S,Thien F,Abramson M

更新日期：2002-04-27 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of teaching general practitioners skills in brief cognitive behaviour therapy. DESIGN:Parallel group, cluster randomised, controlled trial of an educational package on cognitive behaviour therapy. SETTING:General practices in north London. PARTICIPANTS:84 general practitioner pr...

journal_title：BMJ (Clinical research ed.)

authors： King M,Davidson O,Taylor F,Haines A,Sharp D,Turner R

更新日期：2002-04-20 00:00:00

abstract：OBJECTIVES:To examine whether British South Asian children differ in insulin resistance, adiposity, and cardiovascular risk profile from white children. DESIGN:Cross sectional study. SETTING:Primary schools in 10 British towns. PARTICIPANTS:British children aged 8 to 11 years (227 South Asian and 3415 white); 73 Sou...

journal_title：BMJ (Clinical research ed.)

authors： Whincup PH,Gilg JA,Papacosta O,Seymour C,Miller GJ,Alberti KG,Cook DG

更新日期：2002-03-16 00:00:00

abstract：OBJECTIVE:This study updates work published in 1998, which found that of 47 rating instruments appearing on websites offering health information, 14 described how they were developed, five provided instructions for use, and none reported the interobserver reliability and construct validity of the measurements. DESIGN:...

journal_title：BMJ (Clinical research ed.)

authors： Gagliardi A,Jadad AR

更新日期：2002-03-09 00:00:00

abstract：OBJECTIVES:To determine whether over the counter cough medicines are effective for acute cough in adults. DESIGN:Systematic review of randomised controlled trials. DATA SOURCES:Search of the Cochrane Acute Respiratory Infections Group specialised register, Cochrane Controlled Trials Register, Medline, Embase, and the...

journal_title：BMJ (Clinical research ed.)

authors： Schroeder K,Fahey T

更新日期：2002-02-09 00:00:00

abstract：OBJECTIVES:To measure the prevalence of domestic violence among women attending general practice; test the association between experience of domestic violence and demographic factors; evaluate the extent of recording of domestic violence in records held by general practices; and assess acceptability to women of screeni...

journal_title：BMJ (Clinical research ed.)

authors： Richardson J,Coid J,Petruckevitch A,Chung WS,Moorey S,Feder G

更新日期：2002-02-02 00:00:00

abstract：OBJECTIVE:To determine if sufficient evidence exists to support the use of magnetic resonance angiography as a means of selecting patients with recently symptomatic high grade carotid stenosis for surgery. DESIGN:Systematic review of published research on the diagnostic performance of magnetic resonance angiography, 1...

journal_title：BMJ (Clinical research ed.)

authors： Westwood ME,Kelly S,Berry E,Bamford JM,Gough MJ,Airey CM,Meaney JF,Davies LM,Cullingworth J,Smith MA

更新日期：2002-01-26 00:00:00

abstract：OBJECTIVES:To compare the efficacy and tolerability of butterbur (Petasites hybridus) with cetirizine in patients with seasonal allergic rhinitis (hay fever). DESIGN:Randomised, double blind, parallel group comparison. SETTING:Four outpatient general medicine and allergy clinics in Switzerland and Germany. PARTICIPA...

journal_title：BMJ (Clinical research ed.)

authors： Schapowal A,Petasites Study Group.

更新日期：2002-01-19 00:00:00

abstract：OBJECTIVE:To test whether the relation between income inequality and mortality found in US states is because of different levels of formal education. DESIGN:Cross sectional, multiple regression analysis. SETTING:All US states and the District of Columbia (n=51). DATA SOURCES:US census statistics and vital statistics...

journal_title：BMJ (Clinical research ed.)

authors： Muller A

更新日期：2002-01-05 00:00:00

abstract：OBJECTIVE:To determine whether being overweight in childhood increases adult obesity and risk of disease. DESIGN:Prospective cohort study. SETTING:City of Newcastle upon Tyne. PARTICIPANTS:932 members of thousand families 1947 birth cohort, of whom 412 attended for clinical examination age 50. MAIN OUTCOME MEASURES...

journal_title：BMJ (Clinical research ed.)

authors： Wright CM,Parker L,Lamont D,Craft AW

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVES:To determine the prevalence of antibodies to hepatitis B core antigen, hepatitis C virus, and HIV in entrants to Irish prisons and to examine risk factors for infection. DESIGN:Cross sectional, anonymous survey, with self completed risk factor questionnaire and oral fluid specimen for antibody testing. SET...

journal_title：BMJ (Clinical research ed.)

authors： Long J,Allwright S,Barry J,Reynolds SR,Thornton L,Bradley F,Parry JV

更新日期：2001-11-24 00:00:00

abstract：OBJECTIVES:To determine whether there are important differences in performance between group practices and singlehanded general practitioners and the extent to which any differences are explained by practice characteristics such as deprivation. DESIGN:Cross sectional survey. SETTING:206 singlehanded practices and 606...

journal_title：BMJ (Clinical research ed.)

authors： Hippisley-Cox J,Pringle M,Coupland C,Hammersley V,Wilson A

更新日期：2001-08-11 00:00:00

abstract：OBJECTIVES:To measure the impact of socioeconomic deprivation on rates of teenage pregnancy and the extent of local variation in pregnancy rates in Scotland, and to examine how both have changed over time. DESIGN:Population study using routine data from hospital records, aggregated for small areas. SUBJECTS:Female te...

journal_title：BMJ (Clinical research ed.)

authors： McLeod A

更新日期：2001-07-28 00:00:00

abstract：OBJECTIVES:To develop an easily applicable diagnostic scoring method to determine the presence of peptic ulcers in dyspeptic patients in a primary care setting; to evaluate whether Helicobacter pylori testing adds value to history taking. DESIGN:Cross sectional study. SETTING:General practitioners' offices in the Utr...

journal_title：BMJ (Clinical research ed.)

authors： Weijnen CF,Numans ME,de Wit NJ,Smout AJ,Moons KG,Verheij TJ,Hoes AW

更新日期：2001-07-14 00:00:00

abstract：OBJECTIVES:To describe the menstrual experience of women referred for menstrual problems, in particular menorrhagia (excessive menstrual loss), and to assess associations with reasons for referral given by their general practitioners, the women's understanding of the reasons for their attendance at the hospital clinics...

journal_title：BMJ (Clinical research ed.)

authors： Warner P,Critchley HO,Lumsden MA,Campbell-Brown M,Douglas A,Murray G

更新日期：2001-07-07 00:00:00

abstract：OBJECTIVE:To determine the effectiveness of a brief cognitive behavioural intervention in reducing the incidence of sexually transmitted infections among gay men. DESIGN:Randomised controlled trial with 12 months' follow up. SETTING:Sexual health clinic in London. PARTICIPANTS:343 gay men with an acute sexually tran...

journal_title：BMJ (Clinical research ed.)

authors： Imrie J,Stephenson JM,Cowan FM,Wanigaratne S,Billington AJ,Copas AJ,French L,French PD,Johnson AM,Behavioural Intervention in Gay Men Project Study Group.

更新日期：2001-06-16 00:00:00

abstract：OBJECTIVES:To determine the association between ambulance response time and survival from out of hospital cardiopulmonary arrest and to estimate the effect of reducing response times. DESIGN:Cohort study. SETTING:Scottish Ambulance Service. SUBJECTS:All out of hospital cardiopulmonary arrests due to cardiac disease ...

journal_title：BMJ (Clinical research ed.)

authors： Pell JP,Sirel JM,Marsden AK,Ford I,Cobbe SM

更新日期：2001-06-09 00:00:00

abstract：OBJECTIVE:To determine the effects of perineal massage in the second stage of labour on perineal outcomes. DESIGN:Randomised controlled trial. PARTICIPANTS:At 36 weeks' gestation, women expecting normal birth of a singleton were asked to join the study. Women became eligible to be randomised in labour if they progres...

journal_title：BMJ (Clinical research ed.)

authors： Stamp G,Kruzins G,Crowther C

更新日期：2001-05-26 00:00:00

abstract：OBJECTIVE:To evaluate the effects on suicidal behaviour of legislation limiting the size of packs of paracetamol and salicylates sold over the counter. DESIGN:Before and after study. SETTING:UK population, with detailed monitoring of data from five liver units and seven general hospitals, between September 1996 and S...

journal_title：BMJ (Clinical research ed.)

authors： Hawton K,Townsend E,Deeks J,Appleby L,Gunnell D,Bennewith O,Cooper J

更新日期：2001-05-19 00:00:00

abstract：OBJECTIVES:To compare patients' preference for transdermal fentanyl or sustained release oral morphine, their level of pain control, and their quality of life after treatment. DESIGN:Randomised, multicentre, international, open label, crossover trial. SETTING:35 centres in Belgium, Canada, Denmark, Finland, the Unite...

journal_title：BMJ (Clinical research ed.)

authors： Allan L,Hays H,Jensen NH,de Waroux BL,Bolt M,Donald R,Kalso E

更新日期：2001-05-12 00:00:00

abstract：OBJECTIVE:To determine the effectiveness of exercise as an intervention in the management of depression. DESIGN:Systematic review and meta-regression analysis of randomised controlled trials obtained from five electronic databases (Medline, Embase, Sports Discus, PsycLIT, Cochrane Library) and through contact with exp...

journal_title：BMJ (Clinical research ed.)

authors： Lawlor DA,Hopker SW

更新日期：2001-03-31 00:00:00

abstract：OBJECTIVE:To determine whether elderly people can learn to use the inhaler used to deliver zanamivir (Relenza Diskhaler) as effectively as the Turbohaler and to identify which aspects of inhaler technique are most problematic. DESIGN:Randomised, controlled, intervention study. SETTING:Wards for acute elderly care in ...

journal_title：BMJ (Clinical research ed.)

authors： Diggory P,Fernandez C,Humphrey A,Jones V,Murphy M

更新日期：2001-03-10 00:00:00

abstract：OBJECTIVE:To estimate changes in the risk of autism and assess the relation of autism to the mumps, measles, and rubella (MMR) vaccine. DESIGN:Time trend analysis of data from the UK general practice research database (GPRD). SETTING:General practices in the United Kingdom. SUBJECTS:Children aged 12 years or younger...

journal_title：BMJ (Clinical research ed.)

authors： Kaye JA,del Mar Melero-Montes M,Jick H

更新日期：2001-02-24 00:00:00